Molecular markers of prognosis in astrocytic tumors

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Expression of carbonic anhydrase IX in astrocytic tumors predicts poor prognosis.

PURPOSE Carbonic anhydrase IX (CA IX) is a hypoxia-inducible enzyme, which is associated with neoplastic growth. Ectopic CA IX expression has been observed in several tumors, whose normal counterparts do not express this enzyme. Normal human brain tissue shows only slight or no expression of CA IX. EXPERIMENTAL DESIGN We describe CA IX expression in human diffusely infiltrating astrocytomas. ...

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ژورنال

عنوان ژورنال: Cancer

سال: 2002

ISSN: 0008-543X,1097-0142

DOI: 10.1002/cncr.10544